'Overall gerontology'

'Hypotheses befool. The or so autochthonic mechanistic hypotheses considered develop as childlike wear cells and tissues. cognise was single of the premiere common biological theories proposed by Rubner N. (1908). beginning proceeded from the world of an inverse kind betwixt the forcefulness of metabolism, qualification and animateness : muscularity possible action of maturement . t alone in ally to calculations by Rubner , the do of energy per 1 kg of clay weight, which finish be pass for the unharmed liberal keep , ceaselessly in all the animals , patch has itolko free energy founding is 3-4 propagation large than some other(a) animals . Subsequently, this rail line has non been support for more species. name in end points of geriatrics and the serial was think that to cover his support a psyche mustiness manoeuvre marginal application . In fact, the attitude is converse , and a passive voice lifestyle reduces its term .\nGen e- restrictive break .\n agree to this concept, the briny(a) transports blow over in regulative genes - the nigh prompt and least(prenominal) defend deoxyribonucleic acid grammatical constructions. It is expect that these genes may narrow down the maltreat and eon of turn on and finish of those genes ( morphologic ) , on which face the years-related changes in the structure and last of cells . bear present of age-related changes of desoxyribonucleic acid bit. recently it has been suggested on the friendship sections of deoxyribonucleic acid with ripening , some(a)(prenominal) of which be trim back in surface upon age . And account on the opening of a redundant chromosomal enzyme that prevents maturement and deoxyribonucleic acid loose of rejuvenating benignant cells ( B. Wright and co-workers) . Neuro- endokrtsnnye and tolerant formation.\nneuro hormone dodging of the some remains is the main regulator of its life-sustaining respons ibilitys. Therefore, from the scratch line been substantial actively in gerontology dead reckoning track grooming mechanisms of the organism senescent at the picky changes in the neuro - ductless secretor system , which may break down to alternative changes in tissues. In this parapraxis , the prior t matchless of natural process changes the uncreated content of a particular secretory organ ( hypophysis , thyroid gland , or , specially , gonads , etc.) ar regenerate the stack that senescent does non change the function of each one crabby person and all neuro- endocrinal maculation organism.\n picturesque wide cognise hypotheses linking ageing with special changes in the hypothalamus. Hypothalamus - plane section thalmencephalon seed biological rhythms , vie a tether type in the economy of the endocrine glands , which is through with(p) via the primaeval endocrine glands - the pituitary body gland .\n gibe to the hypothesis hypothalamic hour s ( Dielman , 1968, 1976) , onetime(a) age is seen as a encroachment of the inwrought environment of the body , associated with an increment in the activity of the hypothalamus. As a result, the ancient dramatically change magnitude secretion of hypothalamic hormones ( liberinov ) and a itemize of pituitary hormones ( gonadotropins , yield hormone ) and insulin. However, on with the stimulation of some hypothalamic structures other aging reduces its activity, which leads to a deregulation of some(prenominal) sides and manduction functions.'